O-040 Clinical competence of oocytes with developmental abnormalities

Abstract For decades we have looked for marker of embryo competence. And while come a long way in terms identifying markers related to embryonic competence, lot research is still focused on finding this simple measurable indicator predicting positive outcome the individual treatment. Many potential indicators been evaluated. This includes cumulus oocyte complex, zona pellucida, perivitelline space, polar bodies, vacuoles, refractile SER clusters, cytoplasmic granularity, and many others. some these there are data suggesting prediction negative (for review see Bartolacci et al. 2022). Embryo autonomy may result cleavage development despite lack competence establish pregnancy. pregnancies occur without go all live birth. In study by Lundin into chromosomal constitution after rescuing immature (developmentally abnormal) human oocytes. 15% oocytes developed an only very few appeared chromosomally normal cytogenetic analysis. The concluded that majority hCG exposed not reached MII stage at time pick-up defect consequently GV or MI should be used ART programs. As reproductive specialists our main task assist patients achieving their dream having child. We supposed use combined expertise, knowhow, craftmanship, routine experience optimize chance baby. However, ambition help sometimes lose touch underlying biology reproduction. Oocytes from stimulated ovary like those buy supermarket equal quality. depressing fact 5.0 % first cycle biologically competent around 2/3 cycles, none birth child (Lemmen al 2016). also limited ability determine sperm cells – strongest prognosticator being if they look move “normal” sample. Are getting bit desperate when start normality abnormal as suggested title talk? Have point were patient expectations overrides biological training education resulting low willingness accept dictated biology? reinforced perceptions “we did pay money fertilized/developed/implanted”. evaluation based what happened rather than will happen. At end day, health care professionals well needs no such thing “CLINICAL COMPETENCE OF OOCYTES WITH DEVELOPMENTAL ABNORMALITIES”. consequence indicating lower implantation otherwise ok embryo? It might affect ranking embryos particular cycle, but would willing transfer it anyway needed. don’t increase pregnancy per se. But decrease improved selection between available. Maybe re-focus efforts binary approach “developmental abnormalities” toward more oriented mapping variation” impact thus recognizing multi-factorial nature maturation ongoing developing